MT-2
What Is MT-2?
MT-2 (Melanotan II) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH). It features a lactam bridge for enhanced stability and potency compared to native α-MSH.
Typically supplied as a lyophilized powder (acetate salt form) for reconstitution in research settings.
Mechanism of Action (Research Context)
In laboratory models, MT-2 acts as a potent, non-selective agonist at melanocortin receptors (primarily MC1R, MC3R, MC4R, and MC5R).
MC1R activation drives melanogenesis (increased melanin production) in melanocytes via cAMP/PKA/MITF pathway.
MC4R/MC3R activation modulates central pathways involved in appetite suppression, energy expenditure, and sexual arousal.
Its cyclic structure provides greater metabolic stability and receptor affinity than linear α-MSH.
Key Research Findings and Potential Areas of Study
Preclinical studies have explored MT-2 in models of:
Pigmentation and Photoprotection: Strong induction of melanin synthesis and skin darkening.
Appetite and Metabolism: Reduced food intake and body weight via central melanocortin pathways.
Sexual Function: Facilitation of erectile activity and arousal through MC4R signaling (independent of vascular mechanisms like PDE5 inhibitors).
Other Areas: Neuroprotection, inflammation modulation, and potential effects on energy homeostasis or thermogenesis.
It serves as a valuable tool for investigating melanocortin receptor pharmacology across multiple physiological systems.
Why Researchers Choose MT-2
MT-2 is a widely used, superpotent melanocortin agonist ideal for studying pigmentation pathways, central appetite control, sexual neurobiology, and broader melanocortin receptor functions. Its stability and multi-receptor activity make it a versatile research compound.
Questions about specifications, COA, or research applications? Contact our support team.
All products are for research purposes only. Not intended for human use.
