5-Amino

5-Amino-1MQ (Research Compound)

For Research Use Only – Not for Human Consumption, Diagnostic, or Therapeutic Use.

5-Amino-1MQ is supplied strictly for laboratory and scientific research applications, such as in vitro and in vivo studies on NNMT inhibition, fat metabolism, NAD+ levels, mitochondrial function, obesity models, and metabolic regulation. All information below is for educational and research reference only.

What Is 5-Amino-1MQ?

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic small-molecule compound and a potent, selective inhibitor of Nicotinamide N-Methyltransferase (NNMT). Unlike peptides, it belongs to the quinolinium class and is valued for its high cell permeability.

Molecular Formula: C₁₀H₁₁N₂⁺ (cation)

Molecular Weight: ≈ 159.21 Da (free cation) / ~286 Da (iodide salt)

CAS Number: 42464-96-0

Chemical Name: 5-Amino-1-methylquinolinium

Typically supplied as a lyophilized powder (often as iodide or chloride salt) for reconstitution in research settings.

Mechanism of Action (Research Context)

In laboratory models, 5-Amino-1MQ inhibits NNMT, an enzyme that consumes nicotinamide and methyl groups to produce 1-methylnicotinamide (1-MNA). By blocking NNMT:

•  Preserves intracellular NAD+ levels

•  Enhances sirtuin activity and mitochondrial function

•  Shifts metabolism toward fat oxidation (lipolysis) and away from fat storage (lipogenesis)

•  Improves cellular energy efficiency without suppressing appetite in studied models

This mechanism is explored for its effects on adipose tissue remodeling and metabolic health.

Key Research Findings and Potential Areas of Study

Preclinical (primarily rodent and cell-based) studies show:

•  Significant reductions in body weight, white adipose tissue mass, and adipocyte size in diet-induced obesity models

•  Decreased fat storage and increased fat burning

•  Improved NAD+ levels and mitochondrial performance

•  Potential muscle-sparing effects and enhanced muscle strength/endurance (especially when combined with exercise in aged models)

•  Favorable shifts in lipid profiles (e.g., lower total cholesterol)

It is a valuable tool for studying metabolic regulation, obesity, aging, and NAD+ biology.

Research Considerations

Commonly studied via oral or systemic administration in animal models or added directly to cell cultures. Researchers monitor NNMT activity, NAD+/NADH ratios, body composition, adipose histology, lipid markers, and energy expenditure.

Storage for Research: Lyophilized powder is stable at –20°C. Reconstituted solutions should follow standard handling protocols and be used promptly.

Why Researchers Choose 5-Amino-1MQ

5-Amino-1MQ stands out as a targeted NNMT inhibitor for investigating fat metabolism, energy homeostasis, and longevity pathways. Its small-molecule nature, good permeability, and ability to boost NAD+ make it a unique research compound for metabolic and anti-obesity models.

Questions about specifications, COA, or research applications? Contact our support team.

All products are for research purposes only. Not intended for human use.