TB-500
TB-500 (Research Peptide)
For Research Use Only – Not for Human Consumption, Diagnostic, or Therapeutic Use. TB-500 is supplied strictly for laboratory and scientific research applications, such as in vitro and in vivo studies on tissue repair, wound healing, cell migration, actin regulation, angiogenesis, inflammation modulation, and regenerative processes in muscle, tendon, ligament, and other tissue models. All information below is for educational and research reference only and does not constitute medical advice.
What Is TB-500?
TB-500 is a synthetic heptapeptide (7-amino acid fragment) corresponding to the N-acetylated active domain (amino acids 17–23) of the naturally occurring 43-amino acid protein Thymosin Beta-4 (Tβ4). It is often studied as a research tool representing key functional aspects of the parent Thymosin Beta-4 molecule, particularly its actin-binding and cell-migratory properties. The full Thymosin Beta-4 is a highly conserved peptide present in most eukaryotic cells, involved in cytoskeletal dynamics.
It is typically supplied as a lyophilized powder (acetate salt form) for reconstitution in research settings. Note that some suppliers or studies reference the full-length synthetic Thymosin Beta-4 (43 aa, ~4,963 Da, C₂₁₂H₃₅₀N₅₆O₇₈S), but the term “TB-500” specifically denotes the active heptapeptide fragment in most research peptide contexts.
Key Research Findings and Potential Areas of Study
TB-500 and Thymosin Beta-4 have been investigated in preclinical (animal and cell-based) models focusing on regenerative medicine, orthopedics, and wound healing. Notable observations include:
Wound Healing and Tissue Repair: Accelerated re-epithelialization, wound contraction, and closure in dermal wound models. Promotion of angiogenesis and reduced inflammation in skin, corneal, and internal tissue injury studies.
Musculoskeletal Repair: Support for muscle, tendon, and ligament regeneration in rodent and equine models, with potential enhancements in recovery from strain or trauma through improved cell migration and reduced fibrosis.
Anti-Inflammatory and Protective Effects: Modulation of inflammatory cytokines and protection against cell death in various injury models, including cardiac ischemia and neurological damage.
Angiogenesis and Cell Migration: Stimulation of endothelial cell differentiation and new vessel growth, contributing to improved nutrient delivery and tissue remodeling.
Other Exploratory Areas: Potential roles in cardiac repair, corneal healing, hair follicle regeneration, and neuromuscular recovery, though many findings remain preliminary and context-dependent.
Human clinical data on the synthetic TB-500 fragment is limited; most robust evidence derives from full Tβ4 studies or preclinical work. Some small topical studies on related formulations have explored venous ulcers, but results are mixed and not definitive.
Why Researchers Choose TB-500
TB-500 is a popular research tool for studying cytoskeletal regulation and regenerative processes due to its targeted effects on cell motility and repair pathways. It is frequently paired with other peptides (e.g., in combination models with BPC-157) to explore synergistic tissue healing. Valuable for investigations into:
Actin cytoskeleton dynamics
Wound healing and scar minimization
Soft tissue (muscle, tendon, ligament) regeneration
Angiogenesis and inflammation control in injury models
Storage for Research: Lyophilized powder is stable at –20°C. Reconstituted solutions should be handled per standard peptide protocols (typically with bacteriostatic water) and used promptly to maintain stability.
If you are investigating tissue regeneration, actin-binding peptides, musculoskeletal repair models, or related regenerative biology, TB-500 provides a well-known fragment with a foundation of preclinical data for laboratory exploration.
Questions about specifications, COA, purity, or research applications? Contact our support team—we’re here to support legitimate scientific inquiry.
All products are for research purposes only. Not intended for human use.
