Epithalon
Epithalon (Epitalon) (Research Peptide)
For Research Use Only – Not for Human Consumption, Diagnostic, or Therapeutic Use.
Epithalon is supplied strictly for laboratory and scientific research applications, such as in vitro and in vivo studies on telomerase activation, telomere biology, anti-aging processes, pineal gland function, melatonin regulation, and cellular longevity models. All information below is for educational and research reference only.
What Is Epithalon?
Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide derived from epithalamin, a natural extract from the bovine pineal gland. It consists of four amino acids and is one of the most studied peptides in gerontology and longevity research.
Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: ≈ 390.35 Da
CAS Number: 307297-39-8
Sequence: Ala-Glu-Asp-Gly (AEDG)
Typically supplied as a lyophilized white powder (acetate salt form) for reconstitution in research settings.
Mechanism of Action (Research Context)
In laboratory models, Epithalon primarily acts by upregulating telomerase enzyme activity, which helps maintain or elongate telomeres — the protective caps on chromosomes that shorten with each cell division. Additional studied effects include:
• Modulation of pineal gland activity and melatonin synthesis
• Antioxidant and DNA-protective properties
• Epigenetic regulation of gene expression
• Support for chromatin remodeling and cellular stress resistance
These mechanisms are explored for their potential role in slowing cellular senescence and promoting healthy aging.
Key Research Areas
Preclinical studies (mostly cell culture and animal models) have investigated Epithalon for:
• Telomerase activation and telomere elongation in somatic cells
• Geroprotective (anti-aging) effects and extended cellular lifespan
• Improved melatonin production and circadian rhythm regulation
• Antioxidant activity and reduction of oxidative stress
• Potential support for retinal health, immune function, and tumor suppression in certain models
Research Considerations
Epithalon is commonly studied via subcutaneous, intranasal, or systemic administration in animal models, or added directly to cell cultures. Researchers monitor telomerase activity, telomere length, melatonin levels, oxidative stress markers, and cellular proliferation/senescence indicators.
Storage for Research: Lyophilized powder is stable at –20°C. Reconstituted solutions should follow standard peptide handling protocols.
Why Researchers Choose Epithalon
Epithalon is a leading research tool for studying telomere biology, pineal gland peptides, and longevity pathways. Its ability to activate telomerase makes it highly valued in models focused on cellular aging, regenerative biology, and healthy lifespan extension.
Questions about specifications, COA, or research applications? Contact our support team.
All products are for research purposes only. Not intended for human use.
