Mots-C
MOTS-c (Research Peptide)
For Research Use Only – Not for Human Consumption, Diagnostic, or Therapeutic Use. MOTS-c is supplied strictly for laboratory and scientific research applications, such as in vitro and in vivo studies on mitochondrial function, metabolic regulation, AMPK signaling, insulin sensitivity, energy homeostasis, exercise mimetics, and age-related metabolic models. All information below is for educational and research reference only.
What Is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a naturally occurring 16-amino acid mitochondrial-derived peptide (MDP) encoded by a short open reading frame in the mitochondrial 12S rRNA gene (MT-RNR1). It acts as a signaling molecule that communicates between mitochondria and the nucleus, particularly under metabolic stress or exercise.
Typically supplied as a lyophilized powder (acetate salt form) for reconstitution in research settings.
Key Research Findings and Potential Areas of Study
Preclinical (animal and cell-based) studies show promising effects in metabolic models:
Metabolic Homeostasis: Protection against diet-induced obesity, insulin resistance, and age-related metabolic decline.
Glucose & Insulin Sensitivity: Improved glucose uptake in skeletal muscle and better insulin signaling.
Physical Performance: Enhanced exercise capacity and endurance across young, middle-aged, and old animal models.
Mitochondrial Function: Support for energy production, reduced oxidative stress, and better adaptation to metabolic stress.
Other Areas: Potential roles in bone metabolism, inflammation modulation, and healthy aging.
Most robust data comes from rodent and in vitro models; human clinical evidence remains limited.
Why Researchers Choose MOTS-c
MOTS-c is a unique tool for investigating mitochondrial-nuclear crosstalk, metabolic flexibility, and exercise-like benefits at the cellular level. It is particularly valuable in models of obesity, type 2 diabetes, sarcopenia, and longevity research due to its role as a mitochondrial regulator and exercise mimetic.
Questions about specifications, COA, or research applications? Contact our support team.
All products are for research purposes only. Not intended for human use.
